Effects of intestinal electrical stimulation on postprandial small-bowel motility and transit in dogs
Received 26 May 2006; received in revised form 23 July 2006 published online 18 November 2006.
Abstract
Background
Intestinal electrical stimulation (IES) with long pulses has been reported to inhibit motility as well as accelerate transit of continuous infusion. However, it is unknown whether there is a correlation between the IES-induced alterations in motility and transit and whether there is a difference in transit during IES between continuous infusion and bolus infusion.
Methods
The study was performed in 2 postprandial sessions (control and stimulation) in dogs with 2 pairs of serosal electrodes and 2 intestinal cannulas. Intestinal motility and transit with and without IES were measured by manometry and phenol red, respectively.
Results
IES significantly decreased intestinal motility and increased transit time. There was a significant correlation between motility index and transit during IES.
Conclusions
IES inhibits both intestinal bolus motility and transit. There is correlation between motility and transit during IES.
University of Texas Medical Branch, Division of Gastroenterology, Route 0632, Room 221 Microbiology Bldg., 1108 The Strand, Galveston, TX 77555-0632, USA
ABSTRACT