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Volume 199, Issue 1, Pages e12-e16 (January 2010)


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Human acellular dermal matrix: an innovative tool for diaphragmatic reconstruction in patients with large intra-abdominal tumors

Diego Avella, M.D., Luis J. Garcia, M.D., Niraj J. Gusani, M.D., Mehrdad Nikfarjam, M.D., Ph.D., Serene Shereef, M.D., Eric T. Kimchi, M.D., Kevin F. Staveley-O'Carroll, M.D., Ph.D.Corresponding Author Informationemail address

Received 17 September 2008; received in revised form 10 April 2009 published online 19 October 2009.

Abstract 

Background

Patients presenting with large intra-abdominal tumors often require multivisceral organ resection including partial or complete hemidiaphragm excision to achieve complete gross and microscopic tumor resection.

Methods

The ideal surgical approach to the repair of major diaphragmatic defects, particularly in a contaminated surgical field, is not well defined, but the use of prosthetic mesh in these situations is contraindicated.

Results

We report our experience using human acellular dermal matrix for the repair of large diaphragmatic defects in these patients.

Conclusions

Human acellular dermal matrix is a safe and effective option in the surgical reconstruction of diaphragmatic defects in patients with large intra-abdominal tumors.

Section of Surgical Oncology, Department of Surgery, Penn State College of Medicine, PO Box 850, 500 University Dr., H070, Hershey, PA 17033, USA

Corresponding Author InformationCorresponding author. Tel.: +1-717-531-5965; fax: +1-717-531-3649

PII: S0002-9610(09)00412-7

doi:10.1016/j.amjsurg.2009.04.011


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